IUI
A fertility treatment in which prepared sperm is placed inside the uterus around the time of ovulation
What is IUI?
Intrauterine insemination places prepared sperm directly inside the womb at the moment the egg is released. It removes the journey through the cervix, and it concentrates the sample, so a much larger number of moving sperm arrive near the egg than would after intercourse.
The preparation is done in the laboratory on the day. The semen sample is washed and spun to separate the actively swimming sperm from the fluid, dead cells and debris, and the final volume placed into the womb is well under a millilitre of that concentrated fraction.
It is usually combined with mild stimulation and scan tracking, so the insemination can be timed to within a few hours of ovulation. It asks nothing of you on the day beyond a few minutes on the couch, and no anaesthetic is involved.
What it involves
The cycle is monitored with scans, and once the follicle is mature you are given a trigger injection. The insemination is booked for roughly 24 to 36 hours later. Your partner produces a sample about an hour and a half beforehand, or a frozen or donor sample is thawed to the same schedule.
On the couch you lie as you would for a smear. A speculum is passed, the cervix is wiped clean, and a very fine soft catheter is threaded through the cervical canal into the cavity of the womb. The sperm is injected slowly and the catheter withdrawn. The whole thing takes a few minutes and most women feel nothing more than a brief period-like cramp.
You rest on the couch for ten minutes and then get up and go about your day. Progesterone support is often started that evening, and a pregnancy test is done two weeks later.
Recovery
There is nothing to recover from. You can drive yourself home, go back to work the same afternoon, exercise, travel and have intercourse as normal. Bed rest afterwards does not improve the chance of pregnancy. Light spotting and mild cramping on the day are common.
Judged over months, insemination gives roughly a 10 to 15 percent chance of pregnancy per cycle when the tubes are open and the sperm count is reasonable, and lower where either is compromised or where the woman is over 38. Because the per-cycle figure is modest and the cumulative one plateaus, most clinics plan three to four cycles and then reassess honestly instead of continuing. If those cycles pass without a pregnancy, the discussion turns to IVF, and that is a change of plan and not a failure on your part.
Questions about IUI
Does it hurt?
For most women it feels like a smear test with a brief period-like cramp as the catheter passes the cervix, lasting seconds. The catheter is very fine and soft and no anaesthetic is used. If your cervix is tight or angled it can take a little longer and be more uncomfortable, and your doctor has instruments and techniques to make that easier. Taking a simple painkiller half an hour beforehand is reasonable if you are worried.
What is the chance of pregnancy in one cycle?
Around 10 to 15 percent per cycle when the fallopian tubes are open, the sperm count and movement are reasonable and the cycle is stimulated and tracked. It falls with age, particularly after 38, and with poorer sperm quality. Because the per-cycle figure is modest, the cumulative chance over three to four cycles is what matters, and most clinics reassess after that instead of continuing indefinitely. Ask your clinic for its own figures for your age group.
Do I need to lie down or take time off afterwards?
No. You rest on the couch for about ten minutes and then get up and carry on with your day, including work, driving and exercise. Studies comparing bed rest with normal activity after insemination show no difference in pregnancy rates, and the sperm is inside the womb and cannot fall out. Light spotting and mild cramping on the day are normal. Contact the clinic for fever, offensive discharge or worsening pelvic pain in the days that follow.
Other fertility & reproductive medicine treatments
Evaluation and treatment of factors that may make it difficult to conceive
Day CareAssessment and treatment of male factors that can affect sperm production, quality or delivery
Day CareTalk to a care coordinator about IUI
Leave a number and a care coordinator calls you back with what the treatment involves and which hospital it would be at. They book a consult only if you want one